My ferret keeps hissing at me!?

I adopted her from a family who couldn't keep her. We re-named her, (Tahlulah) gave her a bigger cage, adopted another ferret for her, give her food/water/treats/toys, but she keeps hissing at me! Just now i put her in her cage and sheWOULDN'T stop hissing! The first few weeks we had her she was mellow, would just sit in our arms, was cute and clumsy, now she wont stay still, SPAZZES OUT ALL THE TIME, AND HISSES AT ME AND OUR OTHER FERRET! She also chases the other ferret! Is she being territorial? She is about 2 years old. My other ferret Winnie is only 1 year. What can I do? Winnie will play with us and wont jump out of our arms when we hold her but I dint want to pick favorites but how can I make a better relationship with Tahlulah if she is so squirmy? My last ferret Scruffy was my best friend. he was breaded small so he wastinyy even though he wastheh same age as Tahlulah when he past (over grown heart :'{ ) but he was so sweet and I loved him and he loved me but why can i get a relationship with Talulah?? we have had her for about a year now. She never had another ferret with her. Winnie has. I JUST DONT KNOW WHAT TO DO! I miss Scruffy so much and want to have a good relationship with my new ferrets but... I just cant! how can i fix this? :(